The Tissue Modulation Laboratory


We are an interdisciplinary, international group of clinicians and scientists. Together, we strive to bring the cutting edge of tissue engineering from our workbench to the patient's bedside.

Prof Michael Raghunath

Principal Investigator

In 2003, Prof Raghunath left his home country of Germany to begin a joint appointment as an associate professor of bioengineering and biochemistry at the National University of Singapore (NUS). He has strong academic and industry experience and is the founder and principal investigator of TML.

Read full bio here.

Michelle Lee

Postdoctoral Fellow

Dr Lee graduated with a Bachelor of Life Sciences in 2008 from the NUS. During her undergraduate studies, she worked on the association between respiratory viral infections and acute asthma exacerbation, and the attenuation by EGCG of doxorubicin-induced cardiomyocyte injury in excitation-contraction. At TML, Dr Lee has developed a platform using hBM-MSCs to study adipogenic differentiation and metabolic disease. She received her PhD in 2015.

Adeline Sham

Postdoctoral Fellow

Dr Sham graduated with a BSc (Engineering) from NUS in 2008, with strong experience in in vitro antibody-antigen interactions, patent analysis, and design of meniscal repair implant systems. She joined TML in 2008 and received her PhD in 2014. At TML, she researches drug delivery, stimulation of angiogenesis, tissue engineering, and inhibition of fibrosis. She is currently working on an R&D project funded by ThermoFisher.

Natalie Lim

PhD Student

Natalie received her BSc (Hons) from NUS in 2010. At TML, she is currently exploring the synergy between prolyl hydroxylase inhibitors and lysophospholipids to potentiate angiogenesis for healing of chronic non-healing wounds. Previous work: polyvinylpyrrolidone as a novel macromolecular crowder, release of disparate bioactive growth factors from nanofiber scaffold constructs for wound healing, and the use of polarized Raman Spectroscopy to detect early biomolecular changes in disrupted cartilage.

Yingting Wang

PhD Student

Originally from China, Yingting completed her undergraduate studies at NUS under the French Double Degree Program (FDDP). She majored in bioengineering at NUS while obtaining her diplome d'ingenieur from Ecole Centrale Paris, France. Since August 2012 she has been pursuing a PhD at TML, evaluating blood-derived angiogenic cells for their regenerative capacities.

Anna Goralczyk

PhD Student

Hailing all the way from Poland, Anna originally joined TML for a short internship. Now, two years later, she is still here, working on her PhD Anna is well-known for her love of art, techno music, and her uncanny ability to be productive in the lab at all hours of the day. Her research interests include adipogenesis of human stem cells, and the role of transient receptor potentials in brown adipose tissue.

Rokus Kriszt

PhD Student

Rokus earned his Bachelor's and Master's degrees from the Budapest University of Technology and Economics. He joined TML from Hungary in order to pursue a PhD He specializes in thermoimaging of cell cultures using opticals and fluorescence as a means of detecting minute temperature changes.

Aneesa Iskander

Master's Student

Aneesa received her Bachelor of Engineering from Nanyang Technical University in 2011. After working for three years, she joined TML in 2015 to pursue her master's degree. She is currently exploring gene expression in human brown adipose tissue using microarray analysis.

Stella Chee

Lab Officer

Stella has years of administrative and research experience. Known for her exceptional work ethic, upbeat attitude and love of K-pop, Stella works behind the scenes to make sure the lab operates smoothly. She is currently studying for her Bachelor's degree.

Nithya D/O Selvarajoo

Research Assistant

Nitya is working on the proliferation of human mesenchymal stem cells and xeno-free coating of cell culture plastic. Her work is funded by TSF.

International Graduate Students

Marc van Vijven (Eindhoven University of Technology, Netherlands)
Marc Rabaza Gairi (University of Barcelona, Spain)
Mathilde Koch (Ecole Polytechnique, France)

Visiting Undergraduates

Austin B Miller (University of Texas at Austin, USA)
Vivien Wee (King's College London, UK)
Yannick Nossim (University of Würzburg, Germany)

NUS Undergraduates

Michelle Lin (Biomedical Engineering)
Jarrod Sim (Biomedical Engineering)


Ricky Lareau (Postdoctoral Fellow)
Dimitrios Zeugolis (Postdoctoral Fellow)
Yuensi Wang (PhD Student)
Irma Irsianti (PhD Student)
Clarice Chen (PhD Student)
Felicia Loe (PhD Student)
Karthik Harve (PhD Student)
Pradeep Paul Panengad (PhD Student)
Yanxian Peng (PhD Student)
Xiu Min Ang (PhD Student)
Anna Blocki (PhD Student)
Zhibo Wang (PhD Student)

and many more...